NOVEL POLYAMINE DERIVATIVES AS POTENT COMPETITIVE INHIBITORS OF TRYPANOSOMA-CRUZI TRYPANOTHIONE REDUCTASE

被引：27

作者：

OSULLIVAN, MC

ZHOU, QB

机构：

[1] Department of Chemistry, Indiana State University, Terre Haute

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 17期

关键词：

D O I：

10.1016/0960-894X(95)00331-M

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The inhibiting effects of several spermidine and spermine derivatives on I: cruzi trypanothione reductase were assessed. Spermidine and spermine derivatives containing hydrophobic aromatic substituents were found to be competitive inhibitors of trypanothione reductase. The most effective compounds tested were N-1,N-8-bis(2-naphthylmethyl)spermidine, N-4,N-8-bis(2-naphthylmethyl)spermine and N-4,N-8-bis(3-phenylpropyl)spermine.

引用

页码：1957 / 1960

页数：4

共 21 条

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