THE INFLUENCE OF GLUCOSE-CONCENTRATION UPON THE TRANSPORT OF LIGHT IN TISSUE-SIMULATING PHANTOMS

被引：128

作者：

KOHL, M ^{[1
]}

ESSENPREIS, M ^{[1
]}

COPE, M ^{[1
]}

机构：

[1] BOEHRINGER MANNHEIM GMBH, D-68305 MANNHEIM, GERMANY

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 1995年 / 40卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1088/0031-9155/40/7/009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The effect of glucose upon the transport of light in tissue-simulating phantoms is shown and its possible application for non-invasive glucose monitoring in diabetic patients is discussed. The aim of this paper is to investigate the physical background of this effect. The presence of glucose in an aqueous solution increases its refractive index and therefore has an influence upon the scattering properties of particles suspended in solution. Experimental data on the effect of glucose upon the scattering coefficient and the phase function of aqueous suspensions of spherical polystyrene particles are presented for near-infrared wavelengths and compared to values predicted by Mie theory. The subsequent effect upon light transport in multiple scattering, tissue-simulating phantoms is demonstrated experimentally in a slab geometry and theoretically by applying diffusion theory. It is furthermore shown that optional measurements in the frequency domain allow changes of absorption and scattering coefficient to be separately determined. The possible magnitude of this glucose effect in tissue in vivo is discussed.

引用

页码：1267 / 1287

页数：21

共 35 条

[1] DETERMINATION OF PHYSIOLOGICAL LEVELS OF GLUCOSE IN AN AQUEOUS MATRIX WITH DIGITALLY FILTERED FOURIER-TRANSFORM NEAR-INFRARED SPECTRA [J].