New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane- Anchored MMPs with Therapeutic Antibodies

被引：62

作者：

Devy, Laetitia ^{[1
]}

Dransfield, Daniel T. ^{[2
]}

机构：

[1] Merck Serono SA, CH-1211 Geneva 20, Switzerland

[2] Dyax Corp, Cell Biol & Translat Res, 300 Technol Sq, Cambridge, MA 02139 USA

来源：

BIOCHEMISTRY RESEARCH INTERNATIONAL | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/191670

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

MMP intervention strategies have met with limited clinical success due to severe toxicities. In particular, treatment with broadspectrum MMP-inhibitors (MMPIs) caused musculoskeletal pain and inflammation. Selectivity may be essential for realizing the clinical potential of MMPIs. Here we review discoveries pinpointing membrane-bound MMPs as mediators of mechanisms underlying cancer and inflammation and as possible therapeutic targets for prevention/treatment of these diseases. We discuss strategies to target these therapeutic proteases using highly selective inhibitory agents (i.e., human blocking antibodies) against individual membrane-bound MMPs.

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页数：11

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