PHASE-I CLINICAL-TRIAL OF AN ACELLULAR PERTUSSIS-VACCINE COMPOSED OF GENETICALLY DETOXIFIED PERTUSSIS TOXIN COMBINED WITH FHA AND 69-KDA

被引：39

作者：

PODDA, A ^{[1
]}

NENCIONI, L ^{[1
]}

MARSILI, I ^{[1
]}

PEPPOLONI, S ^{[1
]}

VOLPINI, G ^{[1
]}

DONATI, D ^{[1
]}

DITOMMASO, A ^{[1
]}

DEMAGISTRIS, MT ^{[1
]}

RAPPUOLI, R ^{[1
]}

机构：

[1] SCLAVO RES CTR,VIA FIORENTINA 1,I-53100 SIENA,ITALY

来源：

VACCINE | 1991年 / 9卷 / 10期

关键词：

PERTUSSIS; ACELLULAR; VACCINE; TRIAL; PT; FHA; 69-KDA; PERTACTIN;

D O I：

10.1016/0264-410X(91)90290-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An acellular pertussis vaccine composed of genetically detoxified pertussis toxin (PT-9K/129G), filamentous haemagglutinin (FHA) and pertactin (69 kDa protein) was evaluated in adult volunteers, in double blind, versus placebo. No fever was reported in either group. Mild local reactions were reported after injection of both vaccine and placebo. After the first dose a marked increase in antibodies to PT, FHA and 69 kDa protein was seen in vaccinated subjects with the exception of one who responded well to PT and FHA but did not show a humoral response to the 69 kDa protein. All vaccinees acquired cellular immunity against the three antigens. No significant variation was observed in the humoral or cellular responses after the second dose.

引用

页码：741 / 745

页数：5

共 22 条

[1]

[Anonymous], 1988, LANCET, Vi, P955

[2] IDENTIFICATION OF A 69-KILODALTON NONFIMBRIAL PROTEIN AS AN AGGLUTINOGEN OF BORDETELLA-PERTUSSIS [J].