IDENTIFICATION OF A CADHERIN CELL-ADHESION RECOGNITION SEQUENCE

被引：337

作者：

BLASCHUK, OW

SULLIVAN, R

DAVID, S

POULIOT, Y

机构：

[1] MONTREAL GEN HOSP, RES INST, DEPT NEUROL, CTR RES NEUROSCI, MONTREAL H3G 1A4, QUEBEC, CANADA

[2] HOP MAISON NEUVE ROSEMONT, RES CTR, MONTREAL H1T 2M4, QUEBEC, CANADA

[3] MCGILL UNIV, DEPT BIOL, MONTREAL H3A 1A1, QUEBEC, CANADA

[4] MONTREAL NEUROL HOSP & INST, MONTREAL H3A 2B4, QUEBEC, CANADA

来源：

DEVELOPMENTAL BIOLOGY | 1990年 / 139卷 / 01期

关键词：

D O I：

10.1016/0012-1606(90)90290-Y

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The molecular mechanisms by which the cadherins interact with one another to promote cell adhesion have not been elucidated. In particular, the amino acid sequences of the cadherin cell adhesion recognition sites have not been determined. Here we demonstrate that synthetic peptides containing the sequence HAV, which is common to all of the cadherins, inhibit two processes (compaction of eight-cell-stage mouse embryos and rat neurite outgrowth on astrocytes) that are known to be mediated by cadherins. The data suggest that the tripeptide HAV is a component of a cadherin cell adhesion recognition sequence. © 1990.

引用

页码：227 / 229

页数：3

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