CP-84,657, A POTENT POLYETHER ANTICOCCIDIAL RELATED TO PORTMICIN AND PRODUCED BY ACTINOMADURA SP

被引:19
作者
DIRLAM, JP
BELTON, AM
BORDNER, J
CULLEN, WP
HUANG, LH
KOJIMA, Y
MAEDA, H
NISHIDA, H
NISHIYAMA, S
OSCARSON, JR
RICKETTS, AP
SAKAKIBARA, T
TONE, J
TSUKUDA, K
机构
[1] Central Research, Pfizer Inc., Groton
[2] Aichi 470-23, Taketoyo
关键词
D O I
10.7164/antibiotics.43.668
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new polyether antibiotic CP-84, 657 (C45H78O14) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53708). Following purification by column chromatography and crystallization, the structure of CP-84,657 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-84,657 is among the most potent anticoccidal agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Treponema hyodysenteriae. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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收藏
页码:668 / 679
页数:12
相关论文
共 26 条
[1]   H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].
BAX, A ;
SUMMERS, MF .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094
[2]   AN IMPROVED METHOD FOR HETERONUCLEAR CHEMICAL-SHIFT CORRELATION BY TWO-DIMENSIONAL NMR [J].
BAX, A ;
MORRIS, GA .
JOURNAL OF MAGNETIC RESONANCE, 1981, 42 (03) :501-505
[3]  
BECKER B, 1964, APPL MICROBIOL, V12, P421
[4]   STRUCTURE OF THE NATURAL ANTIBIOTIC IONOPHORE CP-54,883 [J].
BORDNER, J ;
WATTS, PC ;
WHIPPLE, EB .
JOURNAL OF ANTIBIOTICS, 1987, 40 (11) :1496-1505
[5]   UNIFIED STEREOCHEMICAL MODEL OF POLYETHER ANTIBIOTIC-STRUCTURE AND BIOGENESIS [J].
CANE, DE ;
CELMER, WD ;
WESTLEY, JW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (11) :3594-3600
[6]   SITE OF ACTION OF A BROAD-SPECTRUM ARYLTRIAZINE ANTICOCCIDIAL, CP-25,415 [J].
CHAPPEL, LR ;
HOWES, HL ;
LYNCH, JE .
JOURNAL OF PARASITOLOGY, 1974, 60 (03) :415-420
[7]   SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-HYDROXY-1-METHYL-1,3-DIHYDROFURO[3,4-B]QUINOXALINE 4,9-DIOXIDE AND RELATED COMPOUNDS [J].
DIRLAM, JP ;
CZUBA, LJ ;
DOMINY, BW ;
JAMES, RB ;
PEZZULLO, RM ;
PRESSLITZ, JE ;
WINDISCH, WW .
JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (09) :1118-1121
[8]  
DIRLAM JP, 1989, Patent No. 8906963
[9]  
DIRLAM JP, 1989, Patent No. 328303
[10]  
DIRLAM JP, 1989, Patent No. 272586