STEREOCONTROLLED, 2-DIRECTIONAL, CHAIN SYNTHESIS USING THE BORON ALDOL REACTION AND DOUBLE IRELAND-CLAISEN REARRANGEMENT

被引：15

作者：

PATERSON, I

HULME, AN

WALLACE, DJ

机构：

[1] University Chemical Laboratory, Cambridge, CB2 1EW, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 51期

关键词：

D O I：

10.1016/0040-4039(91)80545-H

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Long-chain, (4E,9E)-unsaturated, diesters can be prepared efficiently by double Ireland-Claisen rearrangements, as in 4 --> 5 --> 6. By combination with appropriate E or Z enol borinate aldol reactions, a high level of stereocontrol can be achieved at the four chiral centres and two trisubstituted double bonds in 11, 15, 30, 31 and 32.

引用

页码：7601 / 7604

页数：4

共 19 条

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