INDUCIBLE CARBOXYPEPTIDASE ACTIVITY IN VANCOMYCIN-RESISTANT ENTEROCOCCI

被引：59

作者：

GUTMANN, L

BILLOTKLEIN, D

ALOBEID, S

KLARE, I

FRANCOUAL, S

COLLATZ, E

VANHEIJENOORT, J

机构：

[1] UNIV PARIS 11,CNRS,UA 1131,F-91405 ORSAY,FRANCE

[2] ROBERT KOCH INST BERLIN,W-3700 WERNINGERODE,GERMANY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 01期

关键词：

D O I：

10.1128/AAC.36.1.77

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vancomycin was found to coinduce DD-carboxypeptidase activity, together with resistance, in eight low- or high-level glycopeptide-resistant strains of enterococci. The constitutively resistant mutant (MT10) of a low-level-resistant strain of Enterococcus faecium (D366) spontaneously expressed a level of carboxypeptidase similar to that of the induced strain D366. Pentapeptide, UDP-MurNac-pentapeptide, as well as D-alanyl-D-alanine were in vitro substrates for the carboxypeptidase which was not inhibited by penicillin. The level of vancomycin resistance correlated roughly with the level of carboxypeptidase activity. We infer from these results that the carboxypeptidase is one component of the glycopeptide resistance mechanism.

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页码：77 / 80

页数：4

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