SYNTHETIC BUTANOLIDE AND TETRAHYDROFURAN LIGNANS WITH PLATELET-ACTIVATING-FACTOR ANTAGONIST ACTIVITY

被引：9

作者：

CORAN, SA

BAMBAGIOTTIALBERTI, M

MELANI, F

GIANNELLINI, V

VINCIERI, FF

MULINACCI, N

SALA, R

MORIGGI, E

机构：

[1] UNIV FLORENCE, DIPARTIMENTO SCI FARMACEUT, VIA GINO CAPPONI 9, I-50121 FLORENCE, ITALY

[2] ZAMBON GRP SPA, I-20091 BRESSO, ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 06期

关键词：

LIGNANS; PAF ANTAGONISTS;

D O I：

10.1016/0223-5234(91)90200-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several butanolide and tetrahydrofuran lignans were synthesized to be comparatively tested as platelet activating factor (PAF) antagonists. In particular, the influence of the tetrahydrofurans ether oxygen as compared with the gamma-lactone system of butanolides was evaluated, showing that the two classes of compounds were practically bioisosters. Molecular modelling and semi-empirical calculation were used to rationalize the collected data.

引用

页码：643 / 650

页数：8

共 17 条

[1]

AUGUSTINE RL, 1985, CATALYTIC HYDROGENAT, V32, P89

[2] NEW SYNTHETIC ROUTE TO BUTANOLIDE LIGNANS BY A RUTHENIUM COMPLEX CATALYZED HYDROGENATION OF THE CORRESPONDING STOBBES FULGENIC ACIDS [J].