共 6 条
- [1] [Anonymous], 1989, NEW ENGL J MED, V321, P129
- [2] LONG JM, 1990, STAT MED, V9, P87
- [3] PETO R, 1978, BIOMEDICINE, V28, P24
- [4] YUSUF S, 1984, STAT MED, V3, P499
- [5] 1983, CIRCULATION, V68, P939
- [6] 1982, LANCET, P1173
GENERALIZING THE RESULTS OF RANDOMIZED CLINICAL-TRIALS
被引：71
作者：
BAILEY, KR
机构：
[1] Section of Biostatistics, Mayo Clinic, Mayo Foundation, Rochester, MN
来源：
CONTROLLED CLINICAL TRIALS
|
1994年
/
15卷
/
01期
关键词：
GENERALIZATION;
HETEROGENEITY;
HYPOTHESIS TESTING;
QUALITATIVE INTERACTION;
D O I：
10.1016/0197-2456(94)90024-8
中图分类号：
R-3 [医学研究方法];
R3 [基础医学];
学科分类号：
1001 ;
摘要：
Many scientific and statistical issues are involved in generalizing the results of randomized clinical trials. This paper examines the issues of heterogeneity of risk and heterogeneity of effect, as well as quantitative vs. qualitative heterogeneity. Generalization of quantitative results to populations at different risk is shown to be problematic, independent of any other considerations. Issues of heterogeneity as they relate to target population and choice of therapy are discussed. A few proposals are offered regarding the design and reporting of trials.
引用
收藏
页码：15 / 23
页数：9
相关论文