LESION DEVELOPMENT IN FOCUSED ULTRASOUND SURGERY - A GENERAL-MODEL

被引:140
作者
HILL, CR
RIVENS, I
VAUGHAN, MG
TERHAAR, GR
机构
[1] Joint Department of Physics, Institute of Cancer Research, Royal Marsden Hospital, Sutton
基金
英国医学研究理事会;
关键词
ACOUSTICS; SURGERY; THERAPEUTICS; ULTRASOUND THERAPY; ULTRASONICS;
D O I
10.1016/0301-5629(94)90066-3
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
An analytical model has been constructed for the process of formation of thermal lesions in tissue, resulting from exposure to intense, highly focused ultrasound beams such as may be used in minimally invasive surgery. The model assumes a Gaussian approximation to beam shape in the focal region and predicts, for any such focal beam, the time delay to initiation of a lesion and the subsequent time course of growth of that lesion in lateral and axial dimensions, taking into account the effects of thermal diffusion and blood perfusion. The necessary approximations and assumptions of the model are considered. Comparison of predictions with experimentally measured data on excised pig liver indicate generally good agreement. Comparisons are also made of this theory with previously published data on exposure-time dependence of lesioning threshold intensity. Deficiencies are identified in existing practice for measuring and reporting acoustic exposures for focused ultrasound surgery, and the proposal is therefore made that a quantity that would be more satisfactory, from the viewpoints both of metrology and biophysical relevance, is the intensity spatially averaged over the area enclosed by the half-pressure-maximum contour in the focal plane, as determined under linear conditions, provisionally denoted as I(SAL)
引用
收藏
页码:259 / 269
页数:11
相关论文
共 28 条
[1]  
BASAURI L, 1962, J PHYSL IEO, P513
[2]   EFFECTS OF PHYSICAL PARAMETERS ON HIGH-TEMPERATURE ULTRASOUND HYPERTHERMIA [J].
BILLARD, BE ;
HYNYNEN, K ;
ROEMER, RB .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1990, 16 (04) :409-420
[3]   ACOUSTIC PROPERTIES OF LESIONS GENERATED WITH AN ULTRASOUND THERAPY SYSTEM [J].
BUSH, NL ;
RIVENS, I ;
TERHAAR, GR ;
BAMBER, JC .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1993, 19 (09) :789-801
[4]  
CARSTENSEN E L, 1974, Journal of Biological Physics, V2, P173, DOI 10.1007/BF02308984
[5]   EFFECT OF BLOOD PERFUSION ON THE ABLATION OF LIVER PARENCHYMA WITH HIGH-INTENSITY FOCUSED ULTRASOUND [J].
CHEN, L ;
TERHAAR, G ;
HILL, CR ;
DWORKIN, M ;
CARNOCHAN, P ;
YOUNG, H ;
BENSTED, JPM .
PHYSICS IN MEDICINE AND BIOLOGY, 1993, 38 (11) :1661-1673
[6]   ABSORPTION OF FINITE-AMPLITUDE FOCUSED ULTRASOUND [J].
DALECKI, D ;
CARSTENSEN, EL ;
PARKER, KJ ;
BACON, DR .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1991, 89 (05) :2435-2447
[7]  
Davidson F, 1991, OUTPUT MEASUREMENTS, P75
[8]  
DUCK FA, 1990, PHYSICAL PROPERTIES
[9]   ESTIMATION OF TRANSIENT TEMPERATURE ELEVATION IN LITHOTRIPSY AND IN ULTRASONOGRAPHY [J].
FILIPCZYNSKI, L ;
WOJCIK, J .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1991, 17 (07) :715-721
[10]   THRESHOLD DOSAGES FOR DAMAGE TO MAMMALIAN LIVER BY HIGH-INTENSITY FOCUSED ULTRASOUND [J].
FRIZZELL, LA .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 1988, 35 (05) :578-581