NEUROGENESIS OF THE AMYGDALOID NUCLEAR-COMPLEX IN THE RHESUS-MONKEY

被引:44
作者
KORDOWER, JH
PIECINSKI, P
RAKIC, P
机构
[1] YALE UNIV, SCH MED, NEUROBIOL SECT, NEW HAVEN, CT 06510 USA
[2] UNIV ILLINOIS, SCH MED, DEPT ANAT & CELL BIOL, CHICAGO, IL 60612 USA
[3] RUSH PRESBYTERIAN ST LUKES MED CTR, RUSH ALZHEIMERS DIS CTR, CHICAGO, IL 60612 USA
来源
DEVELOPMENTAL BRAIN RESEARCH | 1992年 / 68卷 / 01期
关键词
AMYGDALA; NEUROGENESIS; H-3]THYMIDINE; NONHUMAN PRIMATE;
D O I
10.1016/0165-3806(92)90242-O
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The time course of neurogenesis for neurons which comprise the amygdaloid complex in Rhesus monkeys was determined using tritiated thymidine autoradiography. Fourteen pregnant monkeys received injections of tritiated thymidine between embryonic days 27 (E27) and 56 of their 165 day gestation and offspring were sacrificed during the early postnatal period. The first neurons destined for the amygdaloid complex were generated at E33 making them among the earliest postmitotic neurons in the telencephalon. Neurogenesis peaked within all nuclei of the amygdaloid complex between E38 and E48 and had ceased between E50 and E56. While amygdaloid neurogenesis in postnatally sacrificed monkeys displayed a dorsal-to-ventral gradient of radiolabeled neurons, the considerable rotation of the temporal lobe during the latter stages of primate development indicates that neurogenesis in the embryo, during the first third of gestation, actually occurs across a medial-to-lateral gradient. This medial-to-lateral gradient occurs as a smooth wave across the amygdaloid nuclei and does not respect neuroanatomical subdivisions or patterns of connectivity of the amygdaloid nuclei in the Rhesus monkey.
引用
收藏
页码:9 / 15
页数:7
相关论文
共 51 条