ETHNIC-DIFFERENCES IN THE PHARMACOKINETICS OF ORAL NIFEDIPINE

被引:61
作者
AHSAN, CH [1 ]
RENWICK, AG [1 ]
MACKLIN, B [1 ]
CHALLENOR, VF [1 ]
WALLER, DG [1 ]
GEORGE, CF [1 ]
机构
[1] UNIV SOUTHAMPTON,CLIN PHARMACOL GRP,MED & BIOL SCI BLDG,BASSETT CRESCENT E,SOUTHAMPTON SO9 3TU,HANTS,ENGLAND
关键词
NIFEDIPINE; ETHNIC DIFFERENCES; PHARMACOKINETICS;
D O I
10.1111/j.1365-2125.1991.tb05552.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 The pharmacokinetics of a single oral dose of 20 mg nifedipine, given as capsules, has been compared in five South Asian volunteers with data for 27 Caucasian volunteers. 2 The area under the plasma concentration-time curve (AUC) of nifedipine was three fold higher in South Asians (989 +/- 166 ng ml-1 h) than in Caucasians (323 +/- 116 ng ml-1h). 3 The ratio of the AUC of nifedipine to that of the nitropyridine analogue, which is formed largely as a first pass metabolite, was significantly higher in South Asians (4.6 +/- 1.9) than in Caucasians (2.3 +/- 1.1) indicating a lower first pass metabolism in South Asians. 4 The terminal half-lives of nifedipine and the nitropyridine metabolite were significantly greater in South Asians than in Caucasians. 5 Consumption of a spicy curry diet for 3 days by Caucasians did not significantly affect the pharmacokinetics of a single oral dose of nifedipine. 6 The treatment of patients of South Asian origin with nifedipine should be initiated with lower doses than would be given to Caucasians.
引用
收藏
页码:399 / 403
页数:5
相关论文
共 18 条
[1]   THE TRANS-HEPATIC EXTRACTION OF NIFEDIPINE [J].
CHALLENOR, VF ;
WALLER, DG ;
RENWICK, AG ;
GRUCHY, BS ;
GEORGE, CF .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 24 (04) :473-477
[2]   NIFEDIPINE KINETICS AND BIOAVAILABILITY AFTER SINGLE INTRAVENOUS AND ORAL DOSES IN NORMAL SUBJECTS [J].
FOSTER, TS ;
HAMANN, SR ;
RICHARDS, VR ;
BRYANT, PJ ;
GRAVES, DA ;
MCALLISTER, RG .
JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 23 (04) :161-170
[3]  
GIBALDI M, 1982, PHARMACOKINETICS, P56
[4]  
GUENGERICH FP, 1986, J BIOL CHEM, V261, P5051
[5]   POLYMORPHISM OF HUMAN CYTOCHROME-P-450 [J].
GUENGERICH, FP ;
UMBENHAUER, DR ;
CHURCHILL, PF ;
BEAUNE, PH ;
BOCKER, R ;
KNODELL, RG ;
MARTIN, MV ;
LLOYD, RS .
XENOBIOTICA, 1987, 17 (03) :311-316
[6]  
HORSTER FA, 1972, ARZNEI-FORSCHUNG, V22, P330
[7]   PHARMACOKINETICS OF NIFEDIPINE SLOW RELEASE TABLET IN MEXICAN SUBJECTS - FURTHER EVIDENCE FOR AN OXIDATION POLYMORPHISM [J].
HOYOVADILLO, C ;
CASTANEDAHERNANDEZ, G ;
HERRERA, JE ;
VIDALGARATE, J ;
MORENORAMOS, A ;
CHAVEZ, F ;
HONG, E .
JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 29 (09) :816-820
[8]   VARIABILITY IN NIFEDIPINE PHARMACOKINETICS AND DYNAMICS - A NEW OXIDATION POLYMORPHISM IN MAN [J].
KLEINBLOESEM, CH ;
VANBRUMMELEN, P ;
FABER, H ;
DANHOF, M ;
VERMEULEN, NPE ;
BREIMER, DD .
BIOCHEMICAL PHARMACOLOGY, 1984, 33 (22) :3721-3724
[9]   LIQUID-CHROMATOGRAPHIC DETERMINATION OF NIFEDIPINE IN PLASMA AND OF ITS MAIN METABOLITE IN URINE [J].
KLEINBLOESEM, CH ;
VANHARTEN, J ;
VANBRUMMELEN, P ;
BREIMER, DD .
JOURNAL OF CHROMATOGRAPHY, 1984, 308 (JUN) :209-216
[10]   THE P450 GENE SUPERFAMILY - RECOMMENDED NOMENCLATURE [J].
NEBERT, DW ;
ADESNIK, M ;
COON, MJ ;
ESTABROOK, RW ;
GONZALEZ, FJ ;
GUENGERICH, FP ;
GUNSALUS, IC ;
JOHNSON, EF ;
KEMPER, B ;
LEVIN, W ;
PHILLIPS, IR ;
SATO, R ;
WATERMAN, MR .
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1987, 6 (01) :1-11