INVITRO EFFECT OF DOXORUBICIN ON NONPROLIFERATING AND PROLIFERATING EPITHELIAL-CELLS

被引：11

作者：

BARAL, E ^{[1
]}

AUER, G ^{[1
]}

机构：

[1] KAROLINSKA HOSP,RADIUM HEMMET,S-10401 STOCKHOLM,SWEDEN

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 19卷 / 04期

关键词：

DNA; Doxorubicin; Mouse kidney epithelial cells; Nuclear protein;

D O I：

10.1016/0360-3016(90)90019-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

in vitro cultured mouse kidney epithelial cells were exposed for 2 hr tp 0.5,μg/ml of Doxorubicin. The proliferative activity of the cells was determined by combined DNA and total nuclear protein measurements. The sensitivity of the cells to the drug was higher in proliferating cells as compared to non-proliferating ones, that is, those exhibiting low amounts of total nuclear protein per unit DNA. © 1990.

引用

页码：963 / 965

页数：3

共 5 条

[1] NUCLEAR PROTEIN CONTENT AND DNA-HISTONE INTERACTION [J].