2-EVENT MODEL FOR CARCINOGENESIS - BIOLOGICAL, MATHEMATICAL, AND STATISTICAL CONSIDERATIONS

被引：232

作者：

MOOLGAVKAR, SH

LUEBECK, G

机构：

[1] Fred Hutchinson Cancer Research Center, Seattle, Washington, 98104, 1124 Columbia Street

来源：

RISK ANALYSIS | 1990年 / 10卷 / 02期

关键词：

Carcinogenesis; dose‐response; two‐stage model;

D O I：

10.1111/j.1539-6924.1990.tb01053.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A two‐mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time‐dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：323 / 341

页数：19

共 48 条

[1]

[Anonymous], 1986, NUMERICAL RECIPES

[2] THE AGE DISTRIBUTION OF CANCER AND A MULTI-STAGE THEORY OF CARCINOGENESIS [J].