MODULATION OF THYMOCYTE APOPTOSIS BY ISOPROTERENOL AND PROSTAGLANDIN-E2

被引：65

作者：

SUZUKI, K

TADAKUMA, T

KIZAKI, H

机构：

[1] TOKYO DENT COLL,DEPT BIOCHEM,1-2-2 MASAGO,CHIBA 260,JAPAN

[2] KEIO UNIV,SCH MED,DEPT BIOCHEM,SHINJUKU KU,TOKYO 160,JAPAN

[3] KEIO UNIV,SCH MED,DEPT MICROBIOL,SHINJUKU KU,TOKYO 160,JAPAN

来源：

CELLULAR IMMUNOLOGY | 1991年 / 134卷 / 01期

关键词：

D O I：

10.1016/0008-8749(91)90346-D

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Isoproterenol and prostaglandin E2 increased CAMP levels in mouse thymocytes transiently, but failed to induce significant internucleosomal DNA fragmentation in thymocytes with a 24-hr incubation. However, these substances showed synergistic interaction with forskolin in the accumulation of cAMP and DNA fragmentation. The addition of 12-O-tetradecanoyl 13-acetate, an activator of protein kinase C, with isoproterenol or particularly with prostaglandin E2 enhanced DNA fragmentation. These results indicate that an increase in cAMP mediated by isoproterenol or prostaglandin receptor is involved in thymocyte apoptosis through internucleosomal DNA fragmentation in concert with a second signal, the activation of protein kinase C. © 1991.

引用

页码：235 / 240

页数：6

共 22 条

[1] BECKNER SK, 1986, J BIOL CHEM, V261, P3043
[2] BOYER PD, 1988, J IMMUNOL, V140, P2886
[3] BOYTON AL, 1983, ADV CYCLIC NUCLEOTID, V15, P193
[4] COFFEY RG, 1985, FED PROC, V44, P112
[5] COHEN JJ, 1984, J IMMUNOL, V132, P38
[6] KIZAKI H, 1989, J IMMUNOL, V143, P1790
[7] KIZAKI H, 1988, J IMMUNOL, V141, P1652
[8] KIZAKI H, 1990, J BIOL CHEM, V265, P5280
[9] 12-O-TETRADECANOYLPHORBOL 13-ACETATE INDUCES DNA CLEAVAGE AT LINKER REGIONS IN MOUSE THYMOCYTES
KIZAKI, H
SHIMADA, H
ISHIMURA, Y
[J]. JOURNAL OF BIOCHEMISTRY, 1989, 105 (05) : 673 - 675
[10] MCCONKEY DJ, 1989, J IMMUNOL, V143, P1801

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