EXPRESSION OF ALPHA-ISOFORMS OF THE NA,K-ATPASE IN HUMAN HEART

被引：62

作者：

ZAHLER, R

GILMOREHEBERT, M

BALDWIN, JC

FRANCO, K

BENZ, EJ

机构：

[1] YALE UNIV, SCH MED, DEPT INTERNAL MED, NEW HAVEN, CT 06510 USA

[2] YALE UNIV, SCH MED, DEPT THERAPEUT RADIOL, NEW HAVEN, CT 06510 USA

[3] YALE UNIV, SCH MED, DEPT SURG, NEW HAVEN, CT 06510 USA

[4] UNIV PITTSBURGH, SCH MED, DEPT MED, PITTSBURGH, PA 15261 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1149卷 / 02期

关键词：

VENTRICLE; MESSENGER RNA; SODIUM ION PUMP; ATPASE; NA+/K+-; CARDIOMYOPATHY; PULMONARY HYPERTENSION; (HUMAN); (HEART);

D O I：

10.1016/0005-2736(93)90200-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase alpha-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5% alpha1, 15% alpha2 and 22.5% alpha3 on average. There was an increase in expression of the alpha3 isoform in samples from failing hearts, but expression of all three isoforms decreased in pressure-overloaded right ventricle (RV).

引用

页码：189 / 194

页数：6

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