PREPARATION OF A NEW NERVE GUIDE FROM A POLY(L-LACTIDE-CO-6-CAPROLACTONE)

被引：60

作者：

PEREGO, G

CELLA, GD

ALDINI, NN

FINI, M

GIARDINO, R

机构：

[1] UNIV BOLOGNA,IOR,IST RIC CODIVILLA PUTTI,SERV CHIRURG SPERIMENTALE,I-40136 BOLOGNA,ITALY

[2] UNIV BOLOGNA,CATTEDRA FISIOPATOL CHIRURG,I-40136 BOLOGNA,ITALY

来源：

BIOMATERIALS | 1994年 / 15卷 / 03期

关键词：

NERVE GUIDE; POLYLACTIDES; CHARACTERIZATION; DEGRADATION; MECHANICAL PROPERTIES;

D O I：

10.1016/0142-9612(94)90066-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A copolymer of L-lactide and 8-caprolactone (50:50, w/w) was synthesized and characterized. The thermal behaviour of this material did not show any crystallinity for several months; only after more than 1 yr of aging at room temperature and, particularly, in the in vitro degradation tests did it partially crystallize. The values of tensile strength, percent elongation at break and elastic modulus were, respectively, 25 MPa, 490% and 3 MPa. Transparent, elastic nerve guides having inner diameter of 1.3 mm and wall thickness of 175 mu m were prepared.

引用

收藏

页码：189 / 193

页数：5

相关论文

共 12 条

[1] DEGRADATION OF AND TISSUE REACTION TO BIODEGRADABLE POLY(L-LACTIDE) FOR USE AS INTERNAL-FIXATION OF FRACTURES - A STUDY IN RATS [J].

BOS, RRM ;

ROZEMA, FR ;

BOERING, G ;

NIJENHUIS, AJ ;

PENNINGS, AJ ;

VERWEY, AB ;

NIEUWENHUIS, P ;

JANSEN, HWB .

BIOMATERIALS, 1991, 12 (01) :32-36

[2] BIODEGRADABLE POLYMERS FOR USE IN SURGERY - POLYGLYCOLIC-POLY(ACTIC ACID) HOMOPOLYMERS AND COPOLYMERS .1. [J].

GILDING, DK ;

REED, AM .

POLYMER, 1979, 20 (12) :1459-1464

[3] POLYMERIZATION TEMPERATURE EFFECTS ON THE PROPERTIES OF L-LACTIDE AND EPSILON-CAPROLACTONE COPOLYMERS [J].

GRIJPMA, DW ;

PENNINGS, AJ .

POLYMER BULLETIN, 1991, 25 (03) :335-341

[4] HIGH-MOLECULAR-WEIGHT COPOLYMERS OF L-LACTIDE AND EPSILON-CAPROLACTONE AS BIODEGRADABLE ELASTOMERIC IMPLANT MATERIALS [J].

GRIJPMA, DW ;

ZONDERVAN, GJ ;

PENNINGS, AJ .

POLYMER BULLETIN, 1991, 25 (03) :327-333

[5] 2-PLY BIODEGRADABLE NERVE GUIDE - BASIC ASPECTS OF DESIGN, CONSTRUCTION AND BIOLOGICAL PERFORMANCE [J].

HOPPEN, HJ ;

LEENSLAG, JW ;

PENNINGS, AJ ;

VANDERLEI, B ;

ROBINSON, PH .

BIOMATERIALS, 1990, 11 (04) :286-290

[6] POLYLACTONES .13. TRANS-ESTERIFICATION OF POLY(L-LACTIDE) WITH POLY(GLYCOLIDE), POLY(BETA-PROPIOLACTONE), AND POLY(EPSILON-CAPROLACTONE) [J].

KRICHELDORF, HR ;

KREISER, I .

JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY, 1987, A24 (11) :1345-1356

[7] NERVE REGENERATION MODEL AND TROPHIC FACTORS INVIVO [J].

LUNDBORG, G ;

LONGO, FM ;

VARON, S .

BRAIN RESEARCH, 1982, 232 (01) :157-161

[8] POLYURETHANE ELASTOMERS IN SURGERY [J].

LYMAN, DJ ;

SEARE, WJ ;

ALBO, D ;

BERGMAN, S ;

LAMB, J ;

METCALF, LC ;

RICHARDS, K .

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS, 1977, 5 (03) :211-229

[9] HISTOLOGIC ASSESSMENT OF NERVE REGENERATION IN THE RAT [J].

MACKINNON, SE ;

HUDSON, AR ;

HUNTER, DA .

PLASTIC AND RECONSTRUCTIVE SURGERY, 1985, 75 (03) :384-388

[10]

PEREGO G, 1993, MAKROMOL CHEM, V194, P2463