NANOFILTRATION, A NEW SPECIFIC VIRUS ELIMINATION METHOD APPLIED TO HIGH-PURITY FACTOR-IX AND FACTOR-XI CONCENTRATES

被引:90
作者
BURNOUFRADOSEVICH, M [1 ]
APPOURCHAUX, P [1 ]
HUART, JJ [1 ]
BURNOUF, T [1 ]
机构
[1] CTR REG TRANSFUS SANGUINE,SERV FRACTIONNEMENT,F-59012 LILLE,FRANCE
关键词
D O I
10.1111/j.1423-0410.1994.tb01647.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have validated the use of two new regenerated multilayered structured cellulose membranes (BMM), Planova 15 N and Planova 35 N, with respective mean pore sizes of 15 and 35 nm, as a new filtration system to eliminate viruses in highly purified factor IX and fat tor XI concentrates. Virus spiking experiments indicated that single dead-end filtration on the membranes could remove more than 5.7-7.8 log(10) of human immunodeficiency virus, bovine viral diarrhoea virus, porcine pseudorabies virus, reovirus type 3, and simian virus 40, as well as the small non-enveloped viruses, poliovirus Sabin type 1 and bovine parvovirus. In vitro control tests and animal studies (Wessler stasis model, rat hypotension model) of the two concentrates did not reveal any significant differences with the non-nanofiltered material. Viral filtration of plasma derivatives on porous polymeric membranes might be an essential step in the improvement of their viral safety.
引用
收藏
页码:132 / 138
页数:7
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