KILLING AND MUTATION OF CHINESE-HAMSTER V79 CELLS EXPOSED TO ACCELERATED OXYGEN AND NEON IONS

被引：45

作者：

STOLL, U ^{[1
]}

SCHMIDT, A ^{[1
]}

SCHNEIDER, E ^{[1
]}

KIEFER, J ^{[1
]}

机构：

[1] UNIV GIESSEN,STRAHLENZENTRUM,ZELL & STRAHLENBIOPHYS ABT,D-35392 GIESSEN,GERMANY

来源：

RADIATION RESEARCH | 1995年 / 142卷 / 03期

关键词：

D O I：

10.2307/3579138

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutation induction by accelerated heavy ions to 6-thioguanine resistance (HPRT system) in Chinese hamster V79 cells was investigated using oxygen and neon ions with energies between 1.9 and 400 MeV/u, corresponding to LET values between 18 and 754 keV/mu m, respectively. Because of technical limitations most experiments could be performed only once. Inactivation and mutation induction cross sections, sigma(i) and sigma(m), were obtained from the slopes of the exponential survival and the linear mutation induction curves, respectively. Both parameters increased with LET up to about 200 keV/mu m, where the curves separated for the two types of ions. Calculated RBEs were higher for mutation induction than for killing for all LET values. (C) 1995 by Radiation Research Society

引用

页码：288 / 294

页数：7

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