EFFECTS OF ISOZYME-SELECTIVE PHOSPHODIESTERASE INHIBITORS ON EOSINOPHIL INFILTRATION IN THE GUINEA-PIG LUNG

被引：41

作者：

LAGENTE, V ^{[1
]}

MOODLEY, I ^{[1
]}

PERRIN, S ^{[1
]}

MOTTIN, G ^{[1
]}

JUNIEN, JL ^{[1
]}

机构：

[1] INST RECH JOUVEINAL, FRESNES, FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 255卷 / 1-3期

关键词：

PHOSPHODIESTERASE INHIBITOR; EOSINOPHIL; AEROSOL; OVALBUMIN; PAF (PLATELET-ACTIVATING FACTOR); (GUINEA PIG);

D O I：

10.1016/0014-2999(94)90107-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of selective phosphodiesterase isozyme inhibitors on eosinophil infiltration induced by antigen challenge or by exposure to an aerosol of platelet-activating factor (PAF) were investigated in the guinea-pig. Pretreatment 24 h and 3 h before antigen challenge or PAF exposure with theophylline (100 mg/kg), rolipram (5 mg/kg) and Ro 20-1724 (30 mg/kg) significantly reduced the increase in eosinophil numbers in bronchoalveolar lavage fluid. In contrast, milrinone, SK&F 94-120 and zaprinast were ineffective against antigen-induced eosinophil recruitment. Theophylline, rolipram and Ro 20-1724 also significantly reduced the release of eosinophil peroxidase into the bronchoalveolar lavage fluid. It is suggested that inhibitors of type TV phosphodiesterase have anti-inflammatory effects in the airways and may be useful in the treatment of asthma.

引用

页码：253 / 256

页数：4

共 10 条

[1]

BEAVO JA, 1988, ADV SEC MESS PHOSPH, V22, P1

[2] PRIMARY SEQUENCE OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES AND THE DESIGN OF SELECTIVE INHIBITORS [J].