Lack of major changes in ATPase activity in mitochondria from liver, heart, and skeletal muscle of rats upon ageing

被引：24

作者：

Barogi, S ^{[1
]}

Baracca, A ^{[1
]}

Castelli, GP ^{[1
]}

Bovina, C ^{[1
]}

Formiggini, G ^{[1
]}

Marchetti, M ^{[1
]}

Solaini, G ^{[1
]}

Lenaz, G ^{[1
]}

机构：

[1] SCUOLA SUPER SANT ANNA, PISA, ITALY

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1995年 / 84卷 / 02期

关键词：

ageing; ATPase; mitochondria;

D O I：

10.1016/0047-6374(95)01640-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ATP hydrolase activity has been investigated in mitochondria from liver, heart, and skeletal muscle from adult (6 months) and aged (24 months) rats. No significant changes in total ATPase activity were observed in the three tissues, but the oligomycin sensitivity was slightly decreased in heart mitochondria of aged rats. The bicarbonate-induced stimulation of hydrolytic activity was somewhat decreased in mitochondria from aged rats, particularly in liver. No significant change was observed in ATPase activity after release of the endogenous inhibitor protein, IF1. It is concluded that no activity changes to be directly ascribed to the catalytic sector F-1 of the enzyme occur upon ageing, but it cannot be excluded that changes in the membrane sector F-0 occur as a consequence of mtDNA mutations.

引用

页码：139 / 150

页数：12

共 52 条

[1] ENDOGENOUS OXIDATIVE DNA DAMAGE, AGING, AND CANCER [J].