EFFECT OF ORAL DOSES OF A POLYTHIOL RESIN ON EXCRETION OF METHYLMERCURY IN MICE TREATED WITH CYSTEINE, D-PENICILLAMINE OR PHENOBARBITONE

Mice dosed with methylmercury chloride (0.5 to 2.0 mg Hg/kg i.p.) labeled with the 203Hg isotope were given polythiol resin in their food (2% wt/wt). The effect of pretreatment with phenobarbitone, or co-administration of D-penicillamine or L-cysteine, was tested on the efficacy of the resin to accelerate the excretion of methylmercury. The effect of the polythiol resin in enhancing fecal excretion was dependent on the dose of methylmercury, it being significantly greater at doses of 1.0 and 2.0 than at 0.5 mg Hg/kg. In animals given the resin and phenobarbitone (0.1% wt/wt drinking water), fecal excretion was .apprx. 36% greater than in animals given resin alone. Penicillamine (2.5 mg/ml drinking water) actually retarded elimination of methylmercury in animals given the resin. Despite the enhanced efficacy of the resin plus phenobarbitone, the brain levels of methylmercury were not reduced beyond those seen in animals given resin alone. The mechanisms and implications of these effects are discussed.