REGIONAL LOCALIZATION OF POLYMORPHIC MARKERS ON CHROMOSOME-10 BY PHYSICAL AND GENETIC-MAPPING

被引：30

作者：

MATHEW, CGP

WAKELING, W

JONES, E

EASTON, D

FISHER, R

STRONG, C

SMITH, B

CHIN, K

LITTLE, P

NAKAMURA, Y

SHOWS, TB

JONES, C

GOODFELLOW, PJ

POVEY, S

PONDER, BAJ

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE,ENGLAND

[2] INST CANC RES,EPIDEMIOL SECT,SURREY,ENGLAND

[3] ELEANOR ROOSEVELT INST,DENVER,CO

[4] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT BIOCHEM,LONDON SW7 2AZ,ENGLAND

[5] UNIV UTAH,HOWARD HUGES MED INST,SALT LAKE CITY,UT 84112

[6] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263

[7] UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER V6T 1W5,BC,CANADA

[8] UNIV LONDON UNIV COLL,GALTON LAB,MRC,HUMAN BIOCHEM GENET LAB,LONDON WC1E 6BT,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1990年 / 54卷

关键词：

D O I：

10.1111/j.1469-1809.1990.tb00368.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human vimentin gene and a random DNA segment (D10S39) were mapped to the short arm of human chromosome 10 by linkage analysis. A panel of somatic cell hybrids and monosomy cell‐lines, which divide chromosome 10 into seven regions, was used to localize 10 polymorphic markers on this chromosome. The physical map locations obtained correlate well with linkage maps of chromosome 10. Two markers which have been shown to be closely linked to the gene for multiple endocrine neoplasia type 2A map distal to a translocation breakpoint in band 10qll.2 Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：121 / 129

页数：9

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