CHANGES OF SOLUBLE INTERLEUKIN-2, INTERLEUKIN-2 RECEPTOR, T8-ANTIGEN, AND INTERLEUKIN-1 IN THE SERUM OF AUTISTIC-CHILDREN

被引：72

作者：

SINGH, VK ^{[1
]}

WARREN, RP ^{[1
]}

ODELL, JD ^{[1
]}

COLE, P ^{[1
]}

机构：

[1] UTAH STATE UNIV,DEPT BIOL,LOGAN,UT 84322

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1991年 / 61卷 / 03期

关键词：

D O I：

10.1016/S0090-1229(05)80015-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune abnormalities in autistic children led us to study for indirect evidence of immune activation as measured by the serum analysis of soluble interleukin-2 (sIL-2), interleukin-2 receptor (sIL-2R), T8 antigen (sT8), and interleukin-1 (sIL-1). The serum concentration of these soluble antigens was quantitated by enzyme-linked immunosorbant assays. The concentration of sIL-2 and sT8, but not of sIL-2R and sIL-1, antigens was significantly (P<0.05) increased in the sera of autistic children over that in the control healthy children or children with mental retardation (non-Down's syndrome). This finding indirectly indicates that the activation of a subpopulation of T cells occurs in some children with autism. © 1991 Academic Press, Inc.

引用

页码：448 / 455

页数：8

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