THE METABOLIC ROLE OF LEUCOVORIN

被引：108

作者：

STOVER, P ^{[1
]}

SCHIRCH, V ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DEPT NUTR SCI, BERKELEY, CA 94720 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 03期

关键词：

D O I：

10.1016/0968-0004(93)90162-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interest in determining if leucovorin, known chemically as 5-formyltetra-hydrofolate, plays a role in one-carbon metabolism is reemerging. While investigations in the 1940s suggested it was an important donor of one-carbon units in folate-mediated biosynthetic reactions, studies between the 1950s and 1980s disproved this hypothesis and dismissed its presence in biological systems as artifactual. Recently, new data has focused attention on the possible biological function of this compound that is widely used in cancer chemotherapy.

引用

页码：102 / 106

页数：5

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