PIPERIDINE-ETHER BASED HNK(1) ANTAGONISTS .1. DETERMINATION OF THE RELATIVE AND ABSOLUTE STEREOCHEMICAL REQUIREMENTS

被引：135

作者：

HARRISON, T ^{[1
]}

WILLIAMS, BJ ^{[1
]}

SWAIN, CJ ^{[1
]}

BALL, RG ^{[1
]}

机构：

[1] MERCK RES LABS,DEPT BIOPHYS CHEM,RAHWAY,NJ

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)80280-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new series of piperidine-based ethers is described and the relative and absolute stereochemical requirements necessary for high affinity binding to the hNK(1) receptor established. The synthesis of the corresponding pyrrolidine derivative is also presented.

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页码：2545 / 2550

页数：6

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