EXTRACELLULAR SEQUESTRATION AND RELEASE OF FIBROBLAST GROWTH-FACTOR - A REGULATORY MECHANISM

被引：273

作者：

VLODAVSKY, I ^{[1
]}

BARSHAVIT, R ^{[1
]}

ISHAIMICHAELI, R ^{[1
]}

BASHKIN, P ^{[1
]}

FUKS, Z ^{[1
]}

机构：

[1] SLOAN KETTERING MEM CANC CTR,DEPT RADIAT ONCOL,NEW YORK,NY 10021

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 07期

关键词：

D O I：

10.1016/0968-0004(91)90102-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Basic fibroblast growth factor, (bFGF), promotes the formation of new blood capillaries and is sequestered and protected by binding to heparan sulfate (HS), both on the cell surface and in the extracellular matrix. Release of HS-bound bFGF by heparin-like molecules and HS-degrading enzymes (i.e., heparanase) provides a novel mechanism for regulation of the growth of capillary blood vessels in normal and pathological situations. The extra-cellular matrix also serves as a storage depot for other growth factors and enzymes.

引用

页码：268 / 271

页数：4

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