DISTRIBUTION OF I-125 ENDOTHELIN-1,-2,-3 BINDING-SITES IN MAMMALIAN KIDNEYS

被引：7

作者：

FUCHS, E ^{[1
]}

GRONE, HJ ^{[1
]}

SIMON, M ^{[1
]}

LAUE, A ^{[1
]}

机构：

[1] UNIV GOTTINGEN,INST PATHOL,W-3400 GOTTINGEN,GERMANY

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1992年 / 101卷 / 04期

关键词：

D O I：

10.1016/0300-9629(92)90357-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Binding sites for I-125-labeled endothelin (ET) isopeptides ET-1, ET-2 and ET-3 were visualized by autoradiography in the kidneys of man, baboon, rhesus monkey, tree shrew, pig and rat. 2. Highest levels of binding for the three isoforms were observed in the glomeruli, cortical and medullary vessels of baboon, rhesus monkey, pig and rat, whereas there was no noticeable labeling of glomeruli in human and tree shrew kidneys. 3. The enrichment of binding sites depended on the species and peptide investigated, suggesting different affinities and/or densities of a heterogenous population of renal ET receptors.

引用

收藏

页码：775 / 778

页数：4

相关论文

共 13 条

[1] CLONING AND EXPRESSION OF A CDNA-ENCODING AN ENDOTHELIN RECEPTOR [J].

ARAI, H ;

HORI, S ;

ARAMORI, I ;

OHKUBO, H ;

NAKANISHI, S .

NATURE, 1990, 348 (6303) :730-732

[2] MESANGIAL CELL, GLOMERULAR AND RENAL VASCULAR-RESPONSES TO ENDOTHELIN IN THE RAT-KIDNEY - ELUCIDATION OF SIGNAL TRANSDUCTION PATHWAYS [J].

BADR, KF ;

MURRAY, JJ ;

BREYER, MD ;

TAKAHASHI, K ;

INAGAMI, T ;

HARRIS, RC .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (01) :336-342

[3] BINDING-SITES FOR I-125-LABELED ENDOTHELIN-1 IN THE KIDNEYS - DIFFERENTIAL DISTRIBUTION IN RAT, PIG AND MAN DEMONSTRATED BY USING QUANTITATIVE AUTORADIOGRAPHY [J].

DAVENPORT, AP ;

NUNEZ, DJ ;

BROWN, MJ .

CLINICAL SCIENCE, 1989, 77 (02) :129-&

[4] LOCALIZATION AND QUANTIFICATION OF [I-125] ENDOTHELIN BINDING-SITES IN HUMAN FETAL AND ADULT KIDNEYS - RELEVANCE TO RENAL ONTOGENY AND PATHOPHYSIOLOGY [J].

GRONE, HJ ;

LAUE, A ;

FUCHS, E .

KLINISCHE WOCHENSCHRIFT, 1990, 68 (15) :758-767

[5] ENDOTHELIUM-DERIVED CONSTRICTING FACTOR(S) - THE LAST NOVELTY - ENDOTHELIN [J].

KARWATOWSKAPROKOPCZUK, E ;

WENNMALM, A .

CLINICAL PHYSIOLOGY, 1990, 10 (02) :113-121

[6]

KING AJ, 1990, HYPERTENSION PATHOPH, P649

[7] LOCALIZATION OF ENDOTHELIN RECEPTORS IN RAT-KIDNEY [J].

KOHZUKI, M ;

JOHNSTON, CI ;

CHAI, SY ;

CASLEY, DJ ;

MENDELSOHN, FAO .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 160 (01) :193-194

[8] GLOMERULAR ACTIONS OF ENDOTHELIN INVIVO [J].

KON, V ;

YOSHIOKA, T ;

FOGO, A ;

ICHIKAWA, I .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (05) :1762-1767

[9] THE DISCOVERY, THE PRESENT STATE, AND THE FUTURE-PROSPECTS OF ENDOTHELIN [J].

MASAKI, T .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1989, 13 :S1-S4

[10]

Nayler W G, 1990, Trends Pharmacol Sci, V11, P96, DOI 10.1016/0165-6147(90)90188-E