LOSS OF HETEROZYGOSITY ON THE SHORT ARM OF CHROMOSOME-17 IN UTERINE CERVICAL CARCINOMAS

被引：28

作者：

PARK, SY

KANG, YS

KIM, BG

LEE, SH

LEE, ED

LEE, KH

PARK, KB

LEE, JH

机构：

[1] SAMSUNG MED CTR,DEPT OBSTET & GYNECOL,SEOUL 135230,SOUTH KOREA

[2] KOREA CANC CTR HOSP,DEPT OBSTET & GYNECOL,SEOUL,SOUTH KOREA

[3] KOREA CANC CTR HOSP,BIOCHEM LAB,SEOUL,SOUTH KOREA

[4] SAMSUNG MED CTR,CTR CANC RES,DEPT BIOCHEM,SEOUL 135230,SOUTH KOREA

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 79卷 / 01期

关键词：

D O I：

10.1016/0165-4608(94)00103-I

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA samples from 26 cervical carcinoma and normal tissue pairs were studied by restriction fragment length polymorphism (RFLP) analysis to determine the Frequency of loss of heterozygosity (LOH) on 17p. Allelic loss in the p13.1 region of chromosome 17, known to contain the TP53 locus, was not detected in any of 10 informative cases. Instead, LOH was detected on 17p13.3 in eight (40%) of 20 informative cases with at least one of two 17p13.3 markers. Examination of the intragenic region of p53 in the same samples using polymerase chain reaction (PCR)-RFLP analysis showed no LOH in the gene (none of Is informative individuals).

引用

页码：74 / 78

页数：5

共 40 条

[1] CODON-72 POLYMORPHISM OF THE TP53 GENE [J].