THE USE OF GLUCAGON IN A CASE OF CALCIUM-CHANNEL BLOCKER OVERDOSE

被引：40

作者：

DOYON, S

ROBERTS, JR

机构：

[1] Department of Emergency Medicine, Division of Toxicology, Mercy Catholic Medical Center

[2] Department of Emergency Medicine, Medical College of Pennsylvania, Philadelphia

来源：

ANNALS OF EMERGENCY MEDICINE | 1993年 / 22卷 / 07期

关键词：

calcium channel blocker; glucagon;

D O I：

10.1016/S0196-0644(05)80997-7

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The hypotension and myocardial depression that result from calcium channel blocker ingestion often are refractory to standard therapeutic modalities. Anecdotal reports on the use of glucagon have failed to show significant hemodynamic improvement. We report the first case of calcium channel blocker overdose that responded to glucagon. We conclude that glucagon is safe and effective in the management of hemodynamic instability associated with calcium channel blocker poisonings.

引用

页码：1229 / 1233

页数：5

共 35 条

[1] Litovitz, Bailey, Schmitz, Et al., 1990 Annual Report of the American Association of Poison Control Centers National Data Collection System, Am J Emerg Med, 9, pp. 461-509, (1991)
[2] Hirotoshi, Eichelbaum, Clinical pharmacokinetics of verapamil, nifedipine and diltiazem, Clin Phamacokinet, 11, pp. 425-449, (1980)
[3] Schlepper, Thorman, Schwarz, The phamacodynamics of orally taken verapamil and verapamil retard as judged by their negative dromotropic effects, Arzneim Forsch, 25, pp. 1452-1455, (1975)
[4] Ellenhorn, Barceloux, Medical Toxicology Diagnosis and Treatment of Human Poisoning, pp. 195-200, (1988)
[5] Mitchell, Schroeder, Mason, Comparative clinical electrophysiologic effects of diltiazem, verapamil and nifedipine: A review, Am J Cardiol, 49, pp. 629-635, (1982)
[6] Gelbke, Schlicht, Schmidt, Fatal poisoning with verapamil, Arch Toxicol, 37, pp. 89-94, (1977)
[7] Antman, Stone, Muller, Et al., Calcium blocking agents in the treatment of cardiovascular disorders: Part 1. Basic electrophysiologic effects, Ann Intern Med, 93, pp. 875-885, (1980)
[8] Stone, Antman, Muller, Et al., Calcium blocking agents in the treatment of cardiovascular disorders: Part II. Hemodynamic effects and applications, Ann Intern Med, 93, pp. 886-904, (1980)
[9] Lewin, Howland, Calcium channel blockers, Goldfrank's Toxicological Emergencies, pp. 372-374, (1990)
[10] Neugebauer, Comparative cardiovascular actions of verapamil and its major metabolites in the anaesthetized dog, Cardiovasc Res, 12, pp. 247-254, (1978)

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