THE PHARMACOKINETICS OF D-SOTALOL AND D,L-SOTALOL IN HEALTHY-VOLUNTEERS

The pharmacokinetics of d-sotalol has been studied in six healthy volunteers given single doses of 0.25, 0.50, 1, 2 mg·kg-1 i.v. and one 100 mg oral dose in comparison with the kinetics of 1 mg·kg-1 i.v. of dlsotalol. There was no significant difference in the disposition of the d-enantiomer and the racemate. The terminal half-life averaged 7.2 h, and the kinetics was linear, with a mean total clearance of 0.13 l·h-1·kg-1. Renal clearance of d-sotalol represented 56 to 77% of total clearance. The absolute systemic availability of oral d-sotalol was close to 100% and the elimination half-life of the oral-d-enantiomer was similar to that of the i.v. form (7.5 h). © 1990 Springer-Verlag.