PLASMA ASCORBATE LEVELS AND INHIBITION OF THE ANTIOXIDANT ACTIVITY OF CERULOPLASMIN

被引:37
作者
GUTTERIDGE, JMC [1 ]
机构
[1] NATL HEART & LUNG INST,LONDON,ENGLAND
关键词
ANTIOXIDANT; BLEOMYCIN; CERULOPLASMIN; LIPID PEROXIDATION; OXYGEN RADICALS; VITAMIN-C SUPPLEMENTATION;
D O I
10.1042/cs0810413
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1. The copper-containing protein caeruloplasmin has several oxidase activities. 2. Its ability to catalyse the oxidation of ferrous ions to the ferric state (ferroxidase activity) makes it an important antioxidant in vivo. 3. Recent reports have suggested that oral supplementation with vitamin C can inhibit the oxidase activities of caeruloplasmin. 4. As expected, damage to DNA and membrane lipids was stimulated by mixtures of iron salt and ascorbate, and this damage could be inhibited by caeruloplasmin provided the molar ratio of ascorbate to caeruloplasmin was kept sufficiently low. 5. When the molar ratio of ascorbate to caeruloplasmin was greater than 200 substantial loss of ferroxidase antioxidant activity occurred. 6. It is unlikely, however, that oral supplementation with vitamin C can raise plasma levels sufficiently to inhibit caeruloplasmin activity in vivo.
引用
收藏
页码:413 / 417
页数:5
相关论文
共 23 条
[1]   AN ELECTRON-PARAMAGNETIC-RES STUDY OF THE NON-EQUIVALENCE OF THE COPPER SITES OF CERULOPLASMIN [J].
CALABRESE, L ;
CARBONARO, M .
BIOCHEMICAL JOURNAL, 1986, 238 (01) :291-295
[2]  
CASPARY WJ, 1979, MOL PHARMACOL, V16, P256
[3]   INFLUENCE OF ASCORBIC-ACID SUPPLEMENTATION ON COPPER STATUS IN YOUNG-ADULT MEN [J].
FINLEY, EB ;
CERKLEWSKI, FL .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1983, 37 (04) :553-556
[4]   ASCORBATE IS AN OUTSTANDING ANTIOXIDANT IN HUMAN-BLOOD PLASMA [J].
FREI, B ;
ENGLAND, L ;
AMES, BN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6377-6381
[5]  
Gutteridge J M, 1986, Free Radic Res Commun, V2, P143, DOI 10.3109/10715768609088066
[6]   CERULOPLASMIN - PHYSIOLOGICAL AND PATHOLOGICAL PERSPECTIVES [J].
GUTTERIDGE, JMC ;
STOCKS, J .
CRC CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 1981, 14 (04) :257-329
[7]   CERULOPLASMIN - PLASMA-PROTEIN, ENZYME, AND ANTIOXIDANT [J].
GUTTERIDGE, JMC .
ANNALS OF CLINICAL BIOCHEMISTRY, 1978, 15 (NOV) :293-296
[8]   SUPEROXIDE-DEPENDENT FORMATION OF HYDROXYL RADICALS IN THE PRESENCE OF IRON SALTS - DETECTION OF FREE IRON IN BIOLOGICAL-SYSTEMS BY USING BLEOMYCIN-DEPENDENT DEGRADATION OF DNA [J].
GUTTERIDGE, JMC ;
ROWLEY, DA ;
HALLIWELL, B .
BIOCHEMICAL JOURNAL, 1981, 199 (01) :263-265
[9]   OXYGEN FREE-RADICALS AND LIPID-PEROXIDATION - INHIBITION BY THE PROTEIN CERULOPLASMIN [J].
GUTTERIDGE, JMC ;
RICHMOND, R ;
HALLIWELL, B .
FEBS LETTERS, 1980, 112 (02) :269-272