HISTOMORPHOMETRIC STUDY OF ALVEOLAR BONE TURNOVER IN ORTHODONTIC TOOTH MOVEMENT

被引:124
作者
KING, GJ
KEELING, SD
WRONSKI, TJ
机构
[1] UNIV FLORIDA, COLL DENT, DEPT ORTHODONT, GAINESVILLE, FL 32611 USA
[2] UNIV FLORIDA, COLL VET MED, DEPT PHYSIOL SCI, GAINESVILLE, FL 32611 USA
关键词
BONE TURNOVER; TOOTH MOVEMENT; RESORPTION; FORMATION; ORTHODONTIC;
D O I
10.1016/8756-3282(91)90029-I
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Selected histomorphometric parameters were measured in alveolar bone adjacent to rat molars treated with a 40-gram tipping force designed to tip the molar mesially and with a sham procedure. Undecalcified parasagittal sections of teeth and surrounding tissues were prepared for static and dynamic histomorphometry at 1, 3, 5, 7, 10, and 14 days. Initial tooth displacement was assessed by measuring differences between groups in the widths of the day-1 periodontal ligaments (PDL) at various vertical locations and correlating these using linear regression analysis. All parameters were measured in the alveolar bone adjacent to four quadrants around the teeth (mesial-distal; occlusal-apical). Means and standard errors for each parameter in each group were calculated and compared for time- and group-specific differences using ANOVA and pairwise comparisons with Scheffe's multiple comparison tests. In sham-treated rats, bone resorption predominated on the distal alveolar surface, but significant surface-related differences between mesial and distal surfaces in bone formation were not demonstrated. Time-specific effects in bone resorption were not evident on either surface in the shams. These findings suggested that molar distal drift in the sham rat is facilitated by resorption in the distal alveolar bone. PDL width changes in orthodontically-treated rats were greatest in the mesial occlusal half of the root and decayed linearly toward the apex indicating that the greater initial tooth displacement occurred in the occlusal half of the root surface. Histomorphometric parameters of alveolar bone turnover were also seen to be greater in these locations, suggesting that these processes were sensitive to the increased tooth displacement. In orthodontically-treated rats, the total paradental alveolar bone and both pressure (mesial) and tension (distal) surfaces experienced a wave of resorption that lasted for four days, was preceded by an activation period of two days, and was followed by a wave of formation that persisted until the end or the experiment (14 days). The relative balance between bone formation and resorption waves was location-specific, with formation predominant on the tension side and resorption predominant on the pressure. These findings are consistent with the conclusion that pressure and tension initiate similar bone turnover events, and that bone deposition or removal is controlled by the degree of balance between the relative amounts of bone formation and resorption that occur at these sites.
引用
收藏
页码:401 / 409
页数:9
相关论文
共 37 条
[1]  
Baron R., 1983, BONE HISTOMORPHOMETR, P13
[2]  
BARON RA, 1981, DYNAMIC HISTOMORPHOM
[3]   THE EFFECT OF AGE ON TOOTH MOVEMENT AND MINERAL DENSITY IN THE ALVEOLAR TISSUES OF THE RAT [J].
BRIDGES, T ;
KING, G ;
MOHAMMED, A .
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 1988, 93 (03) :245-250
[4]   BONE REMODELING IN RESPONSE TO INVIVO FATIGUE MICRODAMAGE [J].
BURR, DB ;
MARTIN, RB ;
SCHAFFLER, MB ;
RADIN, EL .
JOURNAL OF BIOMECHANICS, 1985, 18 (03) :189-&
[5]  
CULP LA, 1989, FUNCTION PROTEOGLYCA, V2, P745
[6]  
DAVIDOVITCH Z, 1988, DENT CLIN N AM, V32, P411
[7]  
FROST HM, 1985, BONE MINERAL RES, V3, P49
[8]   MECHANICAL STRETCHING INCREASES THE NUMBER OF CULTURED BONE-CELLS SYNTHESIZING DNA AND ALTERS THEIR PATTERN OF PROTEIN-SYNTHESIS [J].
HASEGAWA, S ;
SATO, S ;
SAITO, S ;
SUZUKI, Y ;
BRUNETTE, DM .
CALCIFIED TISSUE INTERNATIONAL, 1985, 37 (04) :431-436
[9]   MEASURING DENTAL DRIFT AND ORTHODONTIC TOOTH MOVEMENT IN RESPONSE TO VARIOUS INITIAL FORCES IN ADULT-RATS [J].
KING, GJ ;
KEELING, SD ;
MCCOY, EA ;
WARD, TH .
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 1991, 99 (05) :456-465
[10]   A THEORETICAL-MODEL FOR STRESS-GENERATED FLUID-FLOW IN THE CANALICULI LACUNAE NETWORK IN BONE TISSUE [J].
KUFAHL, RH ;
SAHA, S .
JOURNAL OF BIOMECHANICS, 1990, 23 (02) :171-180