ENZYMATIC ACYLATION AND ALKOXYCARBONYLATION OF ALPHA-NUCLEOSIDES, XYLO-NUCLEOSIDES, ANHYDRO-NUCLEOSIDES, AND ARABINO-NUCLEOSIDES

被引：30

作者：

MORIS, F ^{[1
]}

GOTOR, V ^{[1
]}

机构：

[1] UNIV OVIEDO,FAC QUIM,DEPT QUIM ORGAN & INORGAN,E-33071 OVIEDO,SPAIN

来源：

TETRAHEDRON | 1993年 / 49卷 / 44期

关键词：

OXIME ESTERS; OXIME CARBONATES; ENZYMATIC ACYLATION; ENZYMATIC ALKOXYCARBONYLATION; REGIOSELECTIVITY;

D O I：

10.1016/S0040-4020(01)80204-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5'-O-acyl and 5'-O-alkoxycarbonyl derivatives of alpha-, anhydro-, xylo - and arabinonucleosides could be obtained through a lipase-mediated reaction with SP 435 lipase (from Candida antartica) by using acetoxyime butyrate or butyric anhydride, together with benzyloxycarbonyl-O-acetoxime as acylating agents Alkoxycarbonylation gave poorer yields than acylation and other lipases tested gave non-selective reaction or not reaction at all.

引用

页码：10089 / 10098

页数：10

共 24 条

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