DIFFERENTIAL BINDING OF TIOCONAZOLE ENANTIOMERS TO HYDROXYPROPYL-BETA-CYCLODEXTRIN STUDIED BY CAPILLARY ELECTROPHORESIS

被引：129

作者：

PENN, SG

GOODALL, DM

LORAN, JS

机构：

[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

[2] PFIZER LTD,CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 636卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)80067-I

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capillary electrophoresis has been used to determine binding constants of tioconazole enantiomers with hydroxypropyl-beta-cyclodexrin (HP-beta-CD), after correcting for changes in mobility with increasing viscosity. The predicted and observed values of enantiomeric mobility difference were found to be maximum at a concentration of HP-beta-CD equal to the reciprocal of the average binding constant.

引用

页码：149 / 152

页数：4

共 12 条

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