Differential regulation by cytokines of human astrocyte nitric oxide production

被引：78

作者：

Hu, SX

Sheng, WS

Peterson, PK

Chao, CC

机构：

[1] MINNEAPOLIS MED RES FDN INC,NEUROIMMUNOBIOL & HOST DEF LAB,MINNEAPOLIS,MN 55404

[2] UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55404

来源：

GLIA | 1995年 / 15卷 / 04期

关键词：

reactive nitrogen intermediates; interleukin-1; interferon-gamma; transforming growth factor-beta; interleukin-1 receptor antagonist protein;

D O I：

10.1002/glia.440150412

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reactive nitrogen intermediates, such as nitric oxide (NO), play an important role in host-defense and injury. Human astrocytes released abundant NO upon stimulation with the pro-inflammatory cytokine interleukin (IL)-1 beta, which was potentiated by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. IL-1 receptor antagonist protein markedly attenuated astrocyte NO production. The anti inflammatory cytokines IL-4 and IL-10 potently suppressed IL-1 beta plus IFN-gamma-stimulated NO, while transforming growth factor-beta preferentially inhibited IL-1 beta plus TNF-alpha-stimulated production of NO. These findings suggest that while IL-1 plays a key role in inducing astrocyte NO production, anti-inflammatory cytokines have the capacity to downregulate NO production by IL-l-stimulated astrocytes. (C) 1995 Wiley-Liss, Inc.

引用

页码：491 / 494

页数：4

共 24 条

[1] INFLAMMATORY CYTOKINES WITHIN THE CENTRAL-NERVOUS-SYSTEM - SOURCES, FUNCTION, AND MECHANISM OF ACTION [J].