NEW TOTAL SYNTHESIS OF BIKAVERIN

被引：133

作者：

BEKAERT, A ^{[1
]}

ANDRIEUX, J ^{[1
]}

PLAT, M ^{[1
]}

机构：

[1] UNIV PARIS SUD,FAC PHARM,CNRS,SDI 6233,CHIM THERAPEUT LAB,5 RUE JB CLEMENT,F-92296 CHATENAY MALABRY,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 20期

关键词：

BIKAVERIN; MANNICH BASES; O-QUINONE - P-QUINONE CONVERSION; NAPHTAZARIN DERIVATIVES; ANTITUMOR AGENTS;

D O I：

10.1016/S0040-4039(00)78863-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

On the basis of non-catalysed thermal condensation of a Mannich base with a phenol, followed by dehydration to an o.quinonic chromene further isomerized to a p.quinonic one, the synthesis of bikaverin 7 has been achieved via a six-step route involving selective dealkylation of bikaverin-dimethylether 6.

引用

页码：2805 / 2806

页数：2

共 8 条

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