APOMETALLOTHIONEIN IN RAT-LIVER

被引：14

作者：

APOSTOLOVA, M

BONTCHEV, PR

NACHEV, C

SIRAKOVA, I

机构：

[1] UNIV SOFIA, FAC CHEM, BOUL JAMES BOURCHIER 1, BU-1126 SOFIA, BULGARIA

[2] UNIV SOFIA, FAC BIOL, BU-1421 SOFIA, BULGARIA

[3] HIGHER MED INST, BU-1431 SOFIA, BULGARIA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 620卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80003-M

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The identification of apometallothionein (AMT) in rat liver by reversed-phase high-performance liquid chromatography (RP-HPLC) after gel permeation was realized in experiments performed both in vivo and in vitro. The reliable assignment of the corresponding AMT peak permitted the detection and determination of AMT in different.groups. of experimental and control rats. In all animals studied (more than 100 rats), AMT was always present in amounts higher than that of metallothionein (MT) or compatible with it. Induction of MT synthesis by CdCl2 subcutaneous injections decreased the AMT level and increased the MT level, but nevertheless the amount of AMT still remained relatively high.

引用

页码：191 / 197

页数：7

共 17 条

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APOSTOLOVA, M
BONTCHEV, PR
NACHEV, C
SIRAKOVA, I
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