NOVEL TANDEM REARRANGEMENT OF A STEROIDAL RING-D CYCLOADDUCT DERIVED FROM 2-CHLOROACRYLONITRILE

被引：10

作者：

BULL, JR

GRUNDLER, C

NIVEN, ML

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 03期

关键词：

D O I：

10.1039/c39930000271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cycloadduct 2 derived from reaction of 3-methoxyestra-1,3,5(10),14,16-pentaen-17-yl acetate 1 with 2-chloroacrylonitrile undergoes a tandem reaction sequence in the presence of alkali, leading to (16(1)R)-3-methoxy-17-oxo-15beta,16(1)-cyclo-14,16beta-ethano-14beta-estra-1,3,5(10)-triene-16(1)-carbonitrile 4, the X-ray crystal structure of which is reported; compound 4 is converted into new ring D bridged analogues of estrone.

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页码：271 / 273

页数：3

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