HIV-INHIBITORY COUMARINS FROM LATEX OF THE TROPICAL RAIN-FOREST TREE CALOPHYLLUM-TEYSMANNII VAR INOPHYLLOIDE

被引：78

作者：

FULLER, RW ^{[1
]}

BOKESCH, HR ^{[1
]}

GUSTAFSON, KR ^{[1
]}

MCKEE, TC ^{[1
]}

CARDELLINA, JH ^{[1
]}

MCMAHON, JB ^{[1
]}

CRAGG, GM ^{[1
]}

SOEJARTO, DD ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,THERAPEUT PROGRAM,FREDERICK,MD 21702

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(01)80543-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an effort to identify an adequate and sustainable natural source of the recently described anti-HIV drug development candidate calanolide A, we undertook chemical and biological studies of the latex exuded from trees of the genus Calophyllum. Although we found that calanolide A was not present in latex from the original source species, C. lanigerum var. austrocoriaceum, we did observe that a related coumarin, costatolide, was abundant in latex of C. teysmannii var. inophylloide. Costatolide is currently being evaluated as a possible alternative to calanolide A for drug development.

引用

页码：1961 / 1964

页数：4

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