THE PRIMARY OXYGEN SENSOR OF THE CAT CAROTID-BODY IS CYTOCHROME ALPHA(3) OF THE MITOCHONDRIAL RESPIRATORY-CHAIN

被引：114

作者：

WILSON, DF ^{[1
]}

MOKASHI, A ^{[1
]}

CHUGH, D ^{[1
]}

VINOGRADOV, S ^{[1
]}

OSANAI, S ^{[1
]}

LAHIRI, S ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT PHYSIOL,PHILADELPHIA,PA 19104

来源：

FEBS LETTERS | 1994年 / 351卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CAROTID BODY; OXYGEN; CHEMOSENSOR; OXYGEN SENSOR; CAT; CARBON MONOXIDE;

D O I：

10.1016/0014-5793(94)00887-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbon monoxide was shown to be competitive with O-2 in oxygen sensing by perfused carotid bodies isolated from cats, afferent electrical activity increasing with either decreasing O-2 or increasing CO. The CO-induced increase in afferent activity was fully reversed by bright light. At submaximal light intensities the extent of reversal, after correcting to equal light intensity of light quanta at each wavelength, was maximal for light of 432 +/- 2 and 590 +/- 2 nm, with a ratio (432/590) of approximately 6. This spectrum is characteristic of the CO compound of mitochondrial cytochrome a(3). The photo-reversible inhibition of oxygen sensing activity by CO accounts for at least 80% of the oxygen chemosensory activity of the carotid body.

引用

页码：370 / 374

页数：5

共 27 条

[1] KINETICS OF LOCAL TISSUE PO2 DECREASE AFTER PERFUSION STOP WITHIN CAROTID-BODY OF CAT INVIVO AND INVITRO [J].