ACTIONS OF (+/-)-7-HYDROXY-N,N-DIPROPYLAMINOTETRALIN (7-OH-DPAT) ON DOPAMINE SYNTHESIS IN LIMBIC AND EXTRAPYRAMIDAL REGIONS OF RAT-BRAIN

被引：24

作者：

BOOTH, RG

BALDESSARINI, RJ

MARSH, E

OWENS, CE

机构：

[1] HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BELMONT,MA 02178

[2] HARVARD UNIV,SCH MED,NEUROSCI PROGRAM,BELMONT,MA 02178

[3] MASSACHUSETTS GEN HOSP,MAILMAN RES CTR,MCLEAN DIV,BELMONT,MA 02178

来源：

BRAIN RESEARCH | 1994年 / 662卷 / 1-2期

关键词：

AMINOTETRALIN; AUTORECEPTOR; D-2; D-3; DOPAMINE; 7-OH-DPAT; (+/-)-7-HYDROXY-N; N-DIPROPYLAMINOTETRALIN; RECEPTOR; TYROSINE HYDROXYLASE;

D O I：

10.1016/0006-8993(94)90827-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The proposed D-3-selective ligand (+/-)-7-hydroxy-N,N-dipropylaminotetralin (7-OH-DPAT) inhibited tyrosine hydroxylase in vitro (IC50 = 0.6-0.7 mu M) and dihydroxyphenylalanine (DOPA) accumulation in vivo (ID50 = 4.8-6.4 mg/kg) in two autoreceptor models in extrapyramidal and limbic tissue in rat forebrain, without consistent regional selectivity. Some limbic selectivity (ID50 = 10 vs. 29 mg/kg) was found in an in vivo model permitting expression of postsynaptic D-3 and D-2 receptor activity. The effects were partially blocked by S(-)-eticlopride alone, and fury after reserpine pretreatment. The results suggest that 7-OH-DPAT activates D-3 or D-2 autoreceptors, alters dopamine storage or release, and may interact with some limbic selectivity at postsynaptic D-3 and D-2 receptors as a partial agonist.

引用

页码：283 / 288

页数：6

共 27 条

[1] EFFECTS OF ISOMERS OF HYDROXYAPORPHINES ON DOPAMINE METABOLISM IN RAT-BRAIN REGIONS [J].