DO NEUROACTIVE STEROIDS CAUSE FATIGUE IN PREGNANCY

被引:9
作者
BIEDERMANN, K [1 ]
SCHOCH, P [1 ]
机构
[1] F HOFFMANN LA ROCHE & CO LTD,PHARMA DIV PRECLIN RES,CH-4002 BASEL,SWITZERLAND
来源
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1995年 / 58卷 / 01期
关键词
FATIGUE; PREGNANCY; NEUROACTIVE STEROIDS; ENDOGENOUS BENZODIAZEPINES;
D O I
10.1016/0028-2243(94)01985-G
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
To elucidate factors causing widespread fatigue in pregnancy we studied plasma samples from 23 healthy pregnant volunteers, measuring endogenous neuroactive steroids, endozepines and benzodiazepines by receptor binding assays. The samples were taken at different gestational ages and the women were asked about their feeling of fatigue at the time of sample collection. We found a significant correlation between fatigue in pregnancy and presence of neuroactive steroid-like activity, but could not detect endogenous benzodiazepine-like factors. These results suggest that neuroactive steroids may be involved in fatigue during pregnancy. Their site of synthesis and their biological role remain unclear.
引用
收藏
页码:15 / 18
页数:4
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