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CHARACTERIZATION OF A LOVO SUBLINE RESISTANT TO A BENZOYL MUSTARD DERIVATIVE OF DISTAMYCIN-A (FCE 24517)

被引：12
作者：
CAPOLONGO, L
MELEGARO, G
BROGGINI, M
MONGELLI, N
GRANDI, M
机构：
[1] IST RICERCHE FARMACOL,I-20157 MILAN,ITALY
[2] FARMITALIA CARLO ERBA SPA,RES CTR,SYNTHET CHEM,I-20123 MILAN,ITALY
来源：
BRITISH JOURNAL OF CANCER | 1993年 / 68卷 / 05期
关键词：
D O I：
10.1038/bjc.1993.454
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin A] (LoVo/24517) are resistant to the selecting agent and related molecules as well as to vinblastine, with marginal or no resistance to other antitumour drugs. Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells. Such results suggest that resistance mechanisms possible specific for this class of compounds are operating.
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页码：916 / 919
页数：4
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