OLIGODENDROCYTE REACTIONS AND CELL-PROLIFERATION MARKERS IN HUMAN DEMYELINATING DISEASES

被引:38
作者
MORRIS, CS
ESIRI, MM
SPRINKLE, TJ
GREGSON, N
机构
[1] RADCLIFFE INFIRM,DEPT CLIN NEUROL,OXFORD OX2 6HE,ENGLAND
[2] MED COLL GEORGIA,DEPT NEUROL & CELL & MOLEC BIOL,AUGUSTA,GA
[3] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DEPT ANAT,LONDON SE1 9RT,ENGLAND
关键词
HUMAN DEMYELINATING DISEASE; OLIGODENDROCYTES; CELL PROLIFERATION; MULTIPLE SCLEROSIS; HIV INFECTION;
D O I
10.1111/j.1365-2990.1994.tb00969.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We have carried out immunocytochemical reactions using antibodies to markers of oligodendrocytes, astrocytes, microglia and proliferating cells (PCNA) in sections of human brain in a variety of demyelinating conditions and human immunodeficiency virus (HIV) infection. In the acute phases of demyelinating diseases we found married reactive changes in oligodendrocytes with hyperplasia and an increased cytoplasmic reaction using antibodies to enzymes involved in myelin formation. Proliferative responses were implied by the hyperplasia and the common finding of clusters of two or three adjacent oligodendrocytes at sites of acute myelin damage. This was borne out by studies using the PCNA antibody which gave negative reactions in normal brain but positive reactions in acute demyelination. Double staining for PCNA and cell markers showed that cells that had entered the cell proliferation cycle were to be found among astrocytes, microglia/macrophages and oligodendrocytes. In chronic demyelinating conditions, numbers of oligodendrocytes were reduced and cells in the proliferative cycle were not present, suggesting that the reactive potential of oligodendrocytes or their precursors and their capacity to respond to demyelination is limited.
引用
收藏
页码:272 / 281
页数:10
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