MHOX AND VERTEBRATE SKELETOGENESIS - THE LONG AND THE SHORT OF IT

被引:13
作者
BRICKELL, PM
机构
[1] The Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, London, W1P 6DB, The Windeyer Building, Cleveland Street
基金
英国惠康基金;
关键词
D O I
10.1002/bies.950170903
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The development of the vertebrate skeleton is under complex genetic control, and good progress is being made towards identifying the genes responsible. A recent paper((1)) contributes to this progress by describing transgenic mice in which the homeobox-containing MHox gene has been disrupted. MHox(-/-) mice have a range of skeletal defects, involving loss or shortening of structures in the skull, face and limb. Puzzling features of the MHox(-/-) mutation, which has similar effects on bones with very different embryological origins and yet spares other bones completely, may hold clues to the mechanisms that shape the skeleton. MHox(-/-) mice, used in conjunction with other skeletal mutants, will be important tools for exploring these mechanisms further.
引用
收藏
页码:750 / 753
页数:4
相关论文
共 26 条
  • [1] CSERJESI P, 1994, J BIOL CHEM, V269, P16740
  • [2] CSERJESI P, 1992, DEVELOPMENT, V115, P1087
  • [3] DAVIS AP, 1994, DEVELOPMENT, V120, P2187
  • [4] ABSENCE OF RADIUS AND ULNA IN MICE LACKING HOXA-11 AND HOXD-11
    DAVIS, AP
    WITTE, DP
    HSIEHLI, HM
    POTTER, SS
    CAPECCHI, MR
    [J]. NATURE, 1995, 375 (6534) : 791 - 795
  • [5] DISRUPTION OF THE HOXD-13 GENE INDUCES LOCALIZED HETEROCHRONY LEADING TO MICE WITH NEOTENIC LIMBS
    DOLLE, P
    DIERICH, A
    LEMEUR, M
    SCHIMMANG, T
    SCHUHBAUR, B
    CHAMBON, P
    DUBOULE, D
    [J]. CELL, 1993, 75 (03) : 431 - 441
  • [6] TOWARD A MOLECULAR UNDERSTANDING OF SKELETAL DEVELOPMENT
    ERLEBACHER, A
    FILVAROFF, EH
    GITELMAN, SE
    DERYNCK, R
    [J]. CELL, 1995, 80 (03) : 371 - 378
  • [7] FRANCIS PH, 1994, DEVELOPMENT, V120, P209
  • [8] REGULATION IN-VITRO OF AN L-CAM ENHANCER BY HOMEOBOX GENES HOXD9 AND HNF-1
    GOOMER, RS
    HOLST, BD
    WOOD, IC
    JONES, FS
    EDELMAN, GM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) : 7985 - 7989
  • [9] HUMAN AND DROSOPHILA HOMEODOMAIN PROTEINS THAT ENHANCE THE DNA-BINDING ACTIVITY OF SERUM RESPONSE FACTOR
    GRUENEBERG, DA
    NATESAN, S
    ALEXANDRE, C
    GILMAN, MZ
    [J]. SCIENCE, 1992, 257 (5073) : 1089 - 1095
  • [10] THE ESTABLISHMENT OF MURINE HOX-1 EXPRESSION DOMAINS DURING PATTERNING OF THE LIMB
    HAACK, H
    GRUSS, P
    [J]. DEVELOPMENTAL BIOLOGY, 1993, 157 (02) : 410 - 422