MHOX AND VERTEBRATE SKELETOGENESIS - THE LONG AND THE SHORT OF IT

被引：13

作者：

BRICKELL, PM

机构：

[1] The Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, London, W1P 6DB, The Windeyer Building, Cleveland Street

来源：

BIOESSAYS | 1995年 / 17卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1002/bies.950170903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of the vertebrate skeleton is under complex genetic control, and good progress is being made towards identifying the genes responsible. A recent paper((1)) contributes to this progress by describing transgenic mice in which the homeobox-containing MHox gene has been disrupted. MHox(-/-) mice have a range of skeletal defects, involving loss or shortening of structures in the skull, face and limb. Puzzling features of the MHox(-/-) mutation, which has similar effects on bones with very different embryological origins and yet spares other bones completely, may hold clues to the mechanisms that shape the skeleton. MHox(-/-) mice, used in conjunction with other skeletal mutants, will be important tools for exploring these mechanisms further.

引用

页码：750 / 753

页数：4

共 26 条

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