KAINIC ACID-DERIVATIVES WITH ANTICONVULSANT ACTIVITY

被引：31

作者：

COLLINS, JF

DIXON, AJ

BADMAN, G

DESARRO, G

CHAPMAN, AG

HART, GP

MELDRUM, BS

机构：

[1] INST PSYCHIAT, DEPT NEUROL, LONDON SE5 8AF, ENGLAND

[2] SIR JOHN CASS SCH SCI & TECHNOL, DEPT CHEM, 31 JEWRY ST, LONDON EC3N 2EY, ENGLAND

来源：

NEUROSCIENCE LETTERS | 1984年 / 51卷 / 03期

关键词：

D O I：

10.1016/0304-3940(84)90405-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

.beta.-Kainic acid, and the glycine and amino-methylphosphonate derivatives of .alpha.- and .beta.-kainic acid, were injected intracerebroventricularly in DBA/2 mice, that show sound-induced seizure responses. An anticonvulsant effect is observed with marked protection against the tonic and clonic phases of the seizure response. ED50 values against clonus are (in .mu.mol); .beta.-kainic acid, 0.09; .beta.-kainylglycine, 0.11; .alpha.-kainylglycine, 0.28; .alpha.-kainylaminomethylphosphonate, 0.31; .beta.-kainylaminomethylphosphonate, > 1.5. A direct convulsant effect occurs after the .alpha.-kainyl derivatives.

引用

页码：371 / 376

页数：6

共 14 条

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