CA 15-3 AND CARCINOEMBRYONIC ANTIGEN IN THE CLINICAL-EVALUATION OF BREAST-CANCER

被引：63

作者：

DNISTRIAN, AM ^{[1
]}

SCHWARTZ, MK ^{[1
]}

GREENBERG, EJ ^{[1
]}

SMITH, CA ^{[1
]}

SCHWARTZ, DC ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT MED,NEW YORK,NY 10021

来源：

CLINICA CHIMICA ACTA | 1991年 / 200卷 / 2-3期

关键词：

BREAST CANCER; TUMOR MARKER; CARCINOMA ASSOCIATED MUCIN ANTIGENS; CA15-3; CEA;

D O I：

10.1016/0009-8981(91)90080-V

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The individual and combined value of CA 15-3 and carcinoembryonic antigen (CEA) as breast cancer tumor markers was investigated in longitudinal studies. Patients included women at high risk for recurrence after primary therapy or undergoing treatment for metastatic disease. During follow-up, recurrent disease was documented in 33 of 39 (85%) patients including 11 with local recurrence and 22 with distant metastases. At the time recurrence was first documented by objective criteria 23 of 33 (70%) of the patients presented with abnormal CA 15-3 levels (> 36.7 U/ml) compared with 19/33 (58%) with abnormal CEA levels (5 ng/ml). Tumor marker elevations predominated in patients with advanced disease indicating that CA 15-3 and CEA are not reliable for the detection of early breast cancer. Both markers were helpful in monitoring therapeutic response since antigen levels correlated closely with disease status.

引用

页码：81 / 93

页数：13

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