PREPARATION OF MONOCLONAL-ANTIBODIES AGAINST THE IL-6 SIGNAL TRANSDUCER, GP130, THAT CAN INHIBIT IL-6-MEDIATED FUNCTIONS

被引：44

作者：

SAITO, T

TAGA, T

MIKI, D

FUTATSUGI, K

YAWATA, H

KISHIMOTO, T

YASUKAWA, K

机构：

[1] TOSOH CORP,BIOTECHNOL RES LAB,2743-1 HAYAKAWA,AYASE SHI,KANAGAWA 252,JAPAN

[2] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,SUITA,OSAKA 565,JAPAN

[3] OSAKA UNIV,SCH MED,DEPT MED 3,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 1993年 / 163卷 / 02期

关键词：

GP130; IL-6; RECEPTOR; IL-6 SIGNAL TRANSDUCER; (ANTIBODY);

D O I：

10.1016/0022-1759(93)90125-Q

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

mAbs specific to human gp130, a signal transducing component of the IL-6 receptor complex, were prepared by immunizing mice with a previously described recombinant human soluble gp130. Some of the mAbs inhibited the IL-6-induced association of soluble gp130 and soluble IL-6 receptor. Three mAbs (GPX7, GPX22 and GPZ35) were shown to inhibit IL-6-mediated biological responses such as Ig production in a human B cell line and proliferative responses of a human Lennert's lymphoma-derived T cell line, a human myeloma cell line, and a mouse pro-B cell line-derived transfectant expressing human gp130.

引用

收藏

页码：217 / 223

页数：7

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